反应详情

In a mixture of 18ml of nitric acid and 30ml of acetic acid 2.76g of methyl 2-(4-hydroxyphenyl)propionate was stirred at -10° to -20° C for 4 hours. The reaction mixture was poured into ice water and extracted with chloroform. The extract was washed with a sodium hydrogen carbonate solution and water and dried over magnesium sulfate. The chloroform was distilled off to give the desired compound in a yield of 2.35g (69%). The physical data of this compound coincided with those of the compound as described above.

1. extractionextracted with chloroform
2. washThe extract was washed with a sodium hydrogen carbonate solution and water
3. dry with materialdried over magnesium sulfate
4. distillationThe chloroform was distilled off