Iodine → HCID 23287897, compound

HRID 3282Notes

Reaction equation

HRID 3282 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][C:10]([C:12]2[C:13]([SH:21])=[N:14][C:15]([N:18]([CH3:20])[CH3:19])=[N:16][CH:17]=2)=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.II>>[CH3:20][N:18]([CH3:19])[C:15]1[N:14]=[C:13]2[S:21][N:9]([CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C:10](=[O:11])[C:12]2=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 807IodineHCID 178418297HCID 178418297, compound

Product 1

HCID 23287897HCID 23287897, compoundYield 85.9%

Procedure

Using the procedure of Example 20, 6.2 g (20.1 mmol) of 2-dimethylamino-4-mercapto-pyrimidine-5-carboxylic acid (2-piperidin-1-yl-ethyl)-amide were treated with 5.08 g (20.0 mmol) of iodine to give 5.31 g of the title compound after recrystallization from ethyl acetate, mp 128°-129° C.

Sources & evidence

ORD record
ord-02fbceb3836e48fcbd825773c2f9dfe9
Source dataset
uspto-grants-1998_03
Patent number
US05733921

Reaction notes

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