Water → HCID 21444312, compound

Participants

Reaction Steps

A mixture of 500 mg. of N4 -acetyl-N1 -(1-cyclopropyl-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl)sulfanilamide and 5 ml. of 10% aqueous sodium hydroxide was heated on the steam bath for 1 hour, diluted with 10 ml. of water, cooled and acidified by gradual addition of 1ml. of acetic acid. The initial oily precipitate quickly solidified and filtration gave 332 mg. of product melting at 128°-133°. Recrystallization from 7 ml. of ethanol gave 120 mg. of N1 -cyclopropyl-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl)sulfanilamide, melting at 134°-136°.

Provenance & Evidence