Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2-(4-Phenyl-4-hydroxypiperidinomethyl)-6,7-dimethoxy-1-tetralone hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | 3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone | HCID 266816 | — |
| 반응물 | 4-Phenylpiperidin-4-ol hydrochloride | HCID 18614383 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(4-Phenyl-4-hydroxypiperidinomethyl)-6,7-dimethoxy-1-tetralone hydrochloride | HCID 6917910 | — |
반응 단계
A mixture of 21.35 g. of 4-phenylpiperidin-4-ol hydrochloride, 20.6 g. of 6,7-dimethoxy-1-tetralone and 8 g. of paraformaldehyde in 200 ml. of ethanol (or isopropanol) is heated under reflux for 4 hours. The solvent is evaporated and the residue is made into a slurry with acetone/ether and is filtered off. 2-(4-phenyl-4-hydroxypiperidinomethyl)-6,7-dimethoxy-1-tetralone hydrochloride, m.p. 175°-177°, is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04016281 |
| 출처 데이터셋 | uspto-grants-1977_04 |
| ORD ID | ord-c1956a658f884b62a58ca734348e8e33 |
| 출처 메모 | uspto-grants-1977_04 |