HCID 21444595, compound → HCID 21444555, compound

HRID 328255Notes

Reaction equation

HRID 328255 reaction equation
Cl.[C:2]1([C:8]2([OH:29])[CH2:13][CH2:12][N:11]([CH2:14][CH:15]3[CH2:24][CH2:23][C:22]4[C:17](=[CH:18][C:19]([N+:25]([O-])=O)=[CH:20][CH:21]=4)[C:16]3=[O:28])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[C:2]1([C:8]2([OH:29])[CH2:13][CH2:12][N:11]([CH2:14][CH:15]3[CH2:24][CH2:23][C:22]4[C:17](=[CH:18][C:19]([NH2:25])=[CH:20][CH:21]=4)[C:16]3=[O:28])[CH2:10][CH2:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 21444595HCID 21444595, compound

Product 1

HCID 21444555HCID 21444555, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.15 g. of 2-(4-phenyl-4-hydroxypiperidinomethyl)-7-nitro-1-tetralone hydrochloride are dissolved in 30 ml. of methanol and are reduced at 20° and 1 atmosphere over 0.3 g. of pre-reduced platinum oxide. After the calculated quantity of hydrogen has been absorbed, the mixture is filtered, evaporated and worked up in the customary manner to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-7-amino-1-tetralone.

Workup

  1. customare reduced at 20°
  2. customAfter the calculated quantity of hydrogen has been absorbed
  3. filtrationthe mixture is filtered
  4. customevaporated

Sources & evidence

ORD record
ord-498794440afb46c192ef04e2b13e6ba7
Source dataset
uspto-grants-1977_04
Patent number
US04016281

Reaction notes

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