反应详情

3.5 g. of 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-amino-1-tetralone are dissolved in 100 ml. of benzene. 5.3 g. of sodium carbonate are added and the mixture is cooled to 10° while a solution of 0.75 g. of acetyl chloride in 50 ml. of benzene is added dropwise at 10° with stirring. The mixture is stirred for 30 minutes. 5.3 g. more of sodium carbonate are added and the mixture is stirred for 3 hours more at 20°. It is then heated under reflux for 10 minutes, filtered and worked up in the customary manner. 2-(4-Phenyl-4-hydroxypiperidinomethyl)-6-acetamido-1-tetralone is obtained.

1. temperaturethe mixture is cooled to 10° while a solution of 0.75 g
2. stirringThe mixture is stirred for 30 minutes
3. stirringthe mixture is stirred for 3 hours more at 20°
4. temperatureIt is then heated
5. temperatureunder reflux for 10 minutes
6. filtrationfiltered