HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 86734633, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(4-Chlorophenyl)-4-hydroxypiperidine | HCID 38282 | — |
| Reactant | 3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone | HCID 266816 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86734633 | HCID 86734633 | — |
Reaction Steps
2 g. of 4-p-chlorophenylpiperidin-4-ol are dissolved in 30 ml. of DMF. 4.05 g. of 2-dimethylaminomethyl-6,7-dimethoxy-1-tetralone methiodide, obtainable by reacting 6,7-dimethoxy-1-tetralone with dimethylamine and formaldehyde and quaternizing the product with CH3I, and 1 g. of Na2CO3 are added and the mixture is stirred for 4 hours at 20° under N2. After the customary work up, 2-(4-p-chlorophenyl-4-hydroxypiperidinomethyl-6,7-dimethoxy-1-tetralone is obtained. Hydrochloride, m.p. 227°-228°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016281 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-4062e4d4486a44bf88fb0028530d33e1 |
| Source note | uspto-grants-1977_04 |