Water → 3-(4-Methylpiperazin-1-yl)carbonyloxy-2-(1,5-naphthyridin-2-yl)isoindolin-1-one

Participants

Reaction Conditions

Reaction Steps

A suspension of sodium hydride (50% dispersion in mineral oil) (1.46 g.) in anhydrous dimethylformamide (80 cc.) is added to a suspension of 3-hydroxy-2-(1,5-naphthyridin-2-yl)isoindolin-1-one (7 g.) in anhydrous dimethylformamide (410 cc.). When the evolution of gas has ceased, a solution of 1-chlorocarbonyl-4-methyl-piperazine (4.6 g.) in anhydrous dimethylformamide (25 cc.) is added dropwise. After stirring for 4 hours, the reaction mixture is poured into water (3,000 cc.) cooled to 13° C. The precipitate is filtered off, washed with water (75 cc.) and then dried to yield 3-(4-methylpiperazin-1-yl)carbonyloxy-2-(1,5-naphthyridin-2-yl)isoindolin-1-one (5.7 g.) melting at 170°-171° C. After recrystallisation from acetonitrile (50 cc.), the products melts at 173° C.

Provenance & Evidence