Water → 6-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone

Participants

Reaction Conditions

Reaction Steps

A solution of silver nitrate (12.1 g.) in water (50 cc.) is added to a solution of 7-chloro-2-(5-chloro-2-dichloromethyl-benzoylamino)-1,8-naphthyridine (9.5 g.) in dimethylformamide (300 cc.) heated to a temperature of about 110° C. The reaction mixture is further heated to a temperature of about 110° C for 20 minutes and the suspension obtained is filtered hot. The filtrate obtained is poured into water (500 cc.) and the product which precipitates is filtered off. Recrystallisation from dimethylformamide gives 6-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (5 g.) melting at 306° C.

Provenance & Evidence