HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-(Trifluoromethyl)phthalic acid | HCID 599039 | — |
| Product | 5-(Trifluoromethyl)isobenzofuran-1,3-dione | HCID 12717789 | 74.7% |
Reaction Steps
4-Trifluoromethyl-phthalic acid (106.6 g.) and acetic anhydride (215 cc.) are heated to the reflux temperature for 30 minutes. After concentration under reduced pressure (30 mm Hg), the residue is stirred with cyclohexane (420 cc.). After filtration and drying, 4-trifluoromethyl-phthalic anhydride (73.5 g.) melting at 54° C is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016274 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-6eae555cb5c84c91b3e011b3515d54ee |
| Source note | uspto-grants-1977_04 |