反应详情

To a stirred suspension of 7 parts of sodamide in 90 parts of benzene maintained at 30°-35° C there is added a solution of α-phenyl-3-pyridylacetonitrile, described in U.S. Pat. No. 3,225,054 in 70 parts of benzene. The mixture is then refluxed for 1 hour, cooled and treated by portionwise addition with one equivalent of 2-morpholinoethyl chloride (J. Chem. Soc. pp 505, 1949) in 45 parts of xylene at 30°-40° C. The resulting mixture is refluxed for 2 hours, cooled, filtered and extracted with dilute hydrochloric acid. The acid extract is rendered alkaline and extracted with ether. The ether extract is treated with gaseous hydrogen chloride to yield the hydrochloride 2-phenyl-2-(3-pyridyl)-2-morpholinoethylbutyronitrile.

1. temperaturemaintained at 30°-35° C
2. temperatureThe mixture is then refluxed for 1 hour
3. temperaturecooled
4. customat 30°-40° C
5. temperatureThe resulting mixture is refluxed for 2 hours
6. temperaturecooled
7. filtrationfiltered
8. extractionextracted with dilute hydrochloric acid
9. extractionThe acid extract
10. extractionextracted with ether
11. extractionThe ether extract
12. additionis treated with gaseous hydrogen chloride