Ethylene Glycol → HCID 86734637, compound

Participants

Reaction Steps

A mixture of the crude enone III, benzene (2.5 l), ethylene glycol (150 ml) and p-toluenesulphonic acid (4.0 g) was refluxed with water separation (Dean-Stark trap) for 17 hrs. cooled and evaporatd at reduced pressure to approximately 500 ml. Dichloromethane (2.5 l) was added; the mixture worked up, the organic solution was evaporated to approximately 700 ml and diluted with ether (1.5l). The ketal IV was obtained in two crops as colorless needles (249 g, 80%); m.p. 174°-175° C.

Provenance & Evidence