Tetrahydrofuran → HCID 10901772, compound

Participants

Reaction Steps

A solution of 800 mg. of the amine-epoxide (XX) in 10 ml. of tetrahydrofuran was added dropwise at room temperature, to a suspension of 50 mg. of lithium aluminum hydride in 5 ml. of dry tetrahydrofuran. After the addition had been completed, the reaction mixture was stirred and refluxed during fifteen minutes. Work up as usual yielded 700 mg. of an oil which was dissolved in ether and the resulting solution was filtered through a celitecharcoal mixture. The filtrate was treated with a saturated solution of hydrochloric acid in ether to yield 720 mg. of a white hydrochloride salt which after recrystallization from methanol melted at 243°-44° C.(dec.). The IR and NMR were consistent with the structure.

Provenance & Evidence