Ethyl pyruvate → 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

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Reaction Steps

In the same manner given in Example 1, 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine and ethyl pyruvate gives 7-chloro-2-[[1-(ethoxycarbonyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine as an oily product. NMR (CDCl3) δ1.20 (t, 3, CH2CH3), 2.25 (2, 3, CH3), 4.23 (q. 2, CH2CH3), 4.50 (broad s, 2, 3-CH2), between 6.95 and 7.6 (m, 9, NH and arom H's).

Provenance & Evidence