HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyruvic Acid → 7-chloro-2-[(1-carboxyethylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyruvic Acid | HCID 1060 | — |
| Reactant | 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine | HCID 12390874 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-chloro-2-[(1-carboxyethylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine | HCID 54054180 | — |
Reaction Steps
To a solution of 2.85 g. (0.01 mole) of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine in 100 ml. of tetrahydrofuran under nitrogen is added with stirring, 0.847 ml. (0.012 mole) of pyruvic acid. After 2.5 hours at room temperature and overnight at 0° C. 7-chloro-2-[(1-carboxyethylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04017492 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-99b632f3833f41ef92f6bbc9b6a487b8 |
| Source note | uspto-grants-1977_04 |