Methyl pyruvate → HCID 54203391, compound

HRID 328393Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:6]=2[CH:20]=1.[C:21]([O:26][CH3:27])(=[O:25])[C:22]([CH3:24])=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:22]([C:21]([O:26][CH3:27])=[O:25])[CH3:24])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:6]=2[CH:20]=1

Participants

Reactant 2

HCID 11748Methyl pyruvate

HCID 12612400HCID 12612400, compound

Product 1

HCID 54203391HCID 54203391, compound

Procedure

In the manner given in Example 1, 7-bromo-2-hydrazino-5-(2-pyridyl)-3H-1,4-benzodiazepine can be stirred with methyl pyruvate at room temperature to give 7-bromo-2-[[1-(methoxycarbonyl)ethylidene]hydrazino]-5-(2-pyridyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record: ord-0acd6b859a1443abaf7eaeeda3737ee1
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04017492

Reaction notes

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