Methyl pyruvate → HCID 54451032, compound

HRID 328396Notes

Reaction equation

[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][NH2:14])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:7]=2[CH:22]=1.[C:25]([O:30][CH3:31])(=[O:29])[C:26]([CH3:28])=O>>[F:24][C:2]([F:1])([F:23])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][N:14]=[C:26]([C:25]([O:30][CH3:31])=[O:29])[CH3:28])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:7]=2[CH:22]=1

Participants

Reactant 2

HCID 11748Methyl pyruvate

HCID 20369395HCID 20369395, compound

Product 1

HCID 54451032HCID 54451032, compound

Procedure

In the manner given in Example 1, 7-(trifluoromethyl)-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be stirred with methyl pyruvate at room temperature to give 7-(trifluoromethyl)-2-[[1-(methoxycarbonyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record: ord-bc62df8f3e70413dbc0d4086e5bef090
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04017492

Reaction notes

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