Methyl pyruvate → HCID 54218423, compound

HRID 328398Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.[C:22]([O:27][CH3:28])(=[O:26])[C:23]([CH3:25])=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:23]([C:22]([O:27][CH3:28])=[O:26])[CH3:25])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1

Participants

Reactant 2

HCID 11748Methyl pyruvate

HCID 4710852HCID 4710852, compound

Product 1

HCID 54218423HCID 54218423, compound

Procedure

In the manner given in Example 1, 7-bromo-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be stirred with methyl pyruvate at room temperature to give 7-bromo-2-[[1-(methoxycarbonyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record: ord-30bffe90c74e49fe98ae93727d81f84d
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04017492

Reaction notes

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