HCID 12562547, compound → HCID 53739968, compound

HRID 328404Notes

Reaction equation

HRID 328404 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH:9]([CH3:14])[N:8]=[C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:6]=2[CH:21]=1.[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][CH2:31][C:32](=O)[C:33]([OH:35])=[O:34])[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:32]([C:33]([OH:35])=[O:34])[CH2:31][CH2:30][CH2:29][N:26]3[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]3)[CH:9]([CH3:14])[N:8]=[C:7]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:6]=2[CH:21]=1

Participants

3

Reactant 2

HCID 12562547HCID 12562547, compoundHCID 21441693HCID 21441693, compound

Product 1

HCID 53739968HCID 53739968, compound

Procedure

In the manner given in Example 13, 7-chloro-2-hydrazino-3-methyl-5-phenyl-3H-1,4-benzodiazepine can be stirred with 5-(4-methylpiperazino)-2-oxopentanoic acid at room temperature to give 7-chloro-2[[1-carboxy-4-(4-methylpiperazino)butylidene]hydrazino]-3-methyl-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-30b590c1de7c4b9a98f245f98b2be448
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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