Diazomethane → HCID 54338271, compound

HRID 328406Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:26]([OH:28])=[O:27])[CH2:15][CH2:16][N:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][OH:25])[CH2:19][CH2:18]3)[CH2:9][N:8]=[C:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:6]=2[CH:35]=1.[N+](=[CH2:38])=[N-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:26]([O:28][CH3:38])=[O:27])[CH2:15][CH2:16][N:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][OH:25])[CH2:19][CH2:18]3)[CH2:9][N:8]=[C:7]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:6]=2[CH:35]=1

Participants

Reactant 2

HCID 9550Diazomethane

HCID 54053043HCID 54053043, compound

Product 1

HCID 54338271HCID 54338271, compound

Procedure

In the manner given in Example 14, 7-chloro-2-[[1-carboxy-3-[4-(2-hydroxyethyl)piperazino]propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-chloro-2-[[1-(methoxycarbonyl)-3-[4-(2-hydroxyethyl)piperazino]-propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record: ord-69a5074ca639402584e40b0272e9ef9d
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04017492

Reaction notes

Loading…