7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine → HCID 54058583, compound

HRID 328410Notes

Reaction equation

HRID 328410 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.O=[C:22]([CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[C:23]([OH:25])=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:22]([C:23]([OH:25])=[O:24])[CH2:26][N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1

Participants

3

Reactant 2

HCID 123908747-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepineHCID 21441584HCID 21441584, compound

Product 1

HCID 54058583HCID 54058583, compound

Procedure

In the manner given in Example 13, 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine can be stirred with 2-oxo-3-pyrrolidinopropionic acid at room temperature to give 7-chloro-2-[(1-carboxy-2-pyrrolidinoethylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-b74a19ec4771438881d5560713671911
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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