Diazomethane → 7-nitro-2[[1-(methoxycarbonyl)-4-piperidinobutylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328413Notes

Reaction equation

HRID 328413 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][N:15]=[C:16]([C:26]([OH:28])=[O:27])[CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:11][N:10]=[C:9]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:8]=2[CH:35]=1)([O-:3])=[O:2].[N+](=[CH2:38])=[N-]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][N:15]=[C:16]([C:26]([O:28][CH3:38])=[O:27])[CH2:17][CH2:18][CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:11][N:10]=[C:9]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:8]=2[CH:35]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 543095357-nitro-2-[(1-carboxy-4-piperidinobutylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Product 1

HCID 540284327-nitro-2[[1-(methoxycarbonyl)-4-piperidinobutylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 14, 7-nitro-2-[(1-carboxy-4-piperidinobutylidene)hydrazino]-5-phenyl-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-nitro-2[[1-(methoxycarbonyl)-4-piperidinobutylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-ff2bd97c647d4718bb33998b1e573c3d
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

Loading…