HCID 4710852, compound → HCID 54473097, compound

HRID 328414Notes

Reaction equation

HRID 328414 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.[CH3:22][O:23][CH2:24][CH2:25][C:26](=O)[C:27]([OH:29])=[O:28]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:26]([C:27]([OH:29])=[O:28])[CH2:25][CH2:24][O:23][CH3:22])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1

Participants

3

Reactant 2

HCID 4710852HCID 4710852, compoundHCID 21441687HCID 21441687, compound

Product 1

HCID 54473097HCID 54473097, compound

Procedure

In the manner given in Example 9, 7-bromo-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be stirred with 4-methoxy-2-oxobutyric acid at room temperature to give 7-bromo-2-[(1-carboxy-3-methoxypropylidene)-hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-4f70b6bdc9344087bcc05348c6bde9da
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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