Diazomethane → HCID 54157166, compound

HRID 328415Notes

Reaction equation

HRID 328415 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:19]([OH:21])=[O:20])[CH2:15][CH2:16][O:17][CH3:18])[CH2:9][N:8]=[C:7]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[C:6]=2[CH:29]=1.[N+](=[CH2:32])=[N-]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:19]([O:21][CH3:32])=[O:20])[CH2:15][CH2:16][O:17][CH3:18])[CH2:9][N:8]=[C:7]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[Cl:28])[C:6]=2[CH:29]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 54473097HCID 54473097, compound

Product 1

HCID 54157166HCID 54157166, compound

Procedure

In the manner given in Example 10, 7-bromo-2-[(1-carboxy-3-methoxypropylidene)hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-bromo-2-[[1-(methoxycarbonyl)-3-methoxypropylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-f074772c05c74297a6835fb3e3686f64
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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