HCID 21441600, compound → HCID 54189904, compound

HRID 328416Notes

Reaction equation

HRID 328416 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][NH2:14])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:7]=2[CH:22]=1.O=[C:26]([CH2:30][CH2:31][N:32]([CH2:36][CH2:37][CH3:38])[CH2:33][CH2:34][CH3:35])[C:27]([OH:29])=[O:28]>>[F:24][C:2]([F:1])([F:23])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][N:14]=[C:26]([C:27]([OH:29])=[O:28])[CH2:30][CH2:31][N:32]([CH2:36][CH2:37][CH3:38])[CH2:33][CH2:34][CH3:35])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[C:7]=2[CH:22]=1

Participants

3

Reactant 2

HCID 21441600HCID 21441600, compoundHCID 21441647HCID 21441647, compound

Product 1

HCID 54189904HCID 54189904, compound

Procedure

In the manner given in Example 13, 7-(trifluoromethyl)-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine can be stirred with 2-oxo-4-(dipropylamino)-butyric acid at room temperature to give 7-(trifluoromethyl)-2-[[1-carboxy-3-(dipropylamino)propylidene]-hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-619bc077498e4a118bab33a50c1457ef
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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