Diazomethane → HCID 53948959, compound

HRID 328417Notes

Reaction equation

[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][N:14]=[C:15]([C:25]([OH:27])=[O:26])[CH2:16][CH2:17][N:18]([CH2:22][CH2:23][CH3:24])[CH2:19][CH2:20][CH3:21])[CH2:10][N:9]=[C:8]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[F:34])[C:7]=2[CH:35]=1.[N+](=[CH2:40])=[N-]>>[F:37][C:2]([F:1])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][N:14]=[C:15]([C:25]([O:27][CH3:40])=[O:26])[CH2:16][CH2:17][N:18]([CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH3:24])[CH2:10][N:9]=[C:8]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[F:34])[C:7]=2[CH:35]=1

Participants

Reactant 2

HCID 9550Diazomethane

HCID 54189904HCID 54189904, compound

Product 1

HCID 53948959HCID 53948959, compound

Procedure

In the manner given in Example 14, 7-(trifluoromethyl)-2-[[1-carboxy-3-(dipropylamino)propylidene]-hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-(trifluoromethyl)-2-[[1-(methoxycarbonyl)-3-(dipropylamino)propylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record: ord-3e707ac75d964442846f627943a88ed8
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04017492

Reaction notes

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