t-butyl pyruvate → HCID 86734643, compound

HRID 328418Notes

Reaction equation

HRID 328418 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[C:6]=2[CH:22]=1.[C:23]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])(=[O:27])[C:24]([CH3:26])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:24]([C:23]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH3:26])[CH2:9][N:8]=[C:7]([C:14]3[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=3[F:20])[C:6]=2[CH:22]=1

Participants

3

Reactant 2

HCID 11309579t-butyl pyruvateHCID 202918237-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine

Product 1

HCID 86734643HCID 86734643, compound

Procedure

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine can be stirred with tert.-butyl pyruvate to give 7-chloro-2-[[1-(t-butyoxycarbonyl)ethylidene]hydrazino]-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-7b1facbcbcfc4abab0d45a9425092de5
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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