Diazomethane → 2-[[1-(methoxycarbonyl)-3-(dimethylamino)-propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328420Notes

Reaction equation

HRID 328420 reaction equation
[C:1]([C:4](=[N:10][NH:11][C:12]1[CH2:18][N:17]=[C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[N:13]=1)[CH2:5][CH2:6][N:7]([CH3:9])[CH3:8])([OH:3])=[O:2].[N+](=[CH2:31])=[N-]>>[CH3:31][O:2][C:1]([C:4](=[N:10][NH:11][C:12]1[CH2:18][N:17]=[C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[N:13]=1)[CH2:5][CH2:6][N:7]([CH3:8])[CH3:9])=[O:3]

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 539803182-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Product 1

HCID 545240022-[[1-(methoxycarbonyl)-3-(dimethylamino)-propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 14, 2-[[1-carboxy-3-(dimethylamino)propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 2-[[1-(methoxycarbonyl)-3-(dimethylamino)-propylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-d26291ae5dd84ef283f3395b34b3b23e
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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