Diazomethane → 7-chloro-2-[[1-(methoxycarbonyl)-4-(dimethylamino)butylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328424Notes

Reaction equation

HRID 328424 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:21]([OH:23])=[O:22])[CH2:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[CH2:9][N:8]=[C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3Cl)[C:6]=2[CH:31]=1.[N+](=[CH2:34])=[N-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:14]([C:21]([O:23][CH3:34])=[O:22])[CH2:15][CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[CH2:9][N:8]=[C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:6]=2[CH:31]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 542941997-chloro-2-[[1-carboxy-4-(dimethylamino)butylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine

Product 1

HCID 542075647-chloro-2-[[1-(methoxycarbonyl)-4-(dimethylamino)butylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 14, 7-chloro-2-[[1-carboxy-4-(dimethylamino)butylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine can be treated with ethereal diazomethane to give 7-chloro-2-[[1-(methoxycarbonyl)-4-(dimethylamino)butylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-310ba3d242764b49b6640af0f392dc05
Source dataset
uspto-grants-1977_04
Patent number
US04017492

Reaction notes

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