反应详情

温度

0 °C

[4-(1-Hydroxy-1-methyl-ethyl)-thiazol-2-yl]-carbamic acid tert-butyl ester (250 mg, 0.92 mmol) was taken into dry dichloromethane and cooled in an ice bath. To this was added trifluoroacetic acid and the mixture stirred at 0° C. for 4 hours. The mixture was evaporated and the residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The organic layer was separated out and the aqueous layer was extracted with dichloromethane. The combined organic extracts were dried over sodium sulfate and evaporated. Chromatography of the residue over silica gel gradient eluted with 1:99 up to 3:97 methanol in dichloromethane gave [4-(1-hydroxy-1-methyl-ethyl)-thiazol-2-yl]-carbamic acid (56 mg, 39%) as a white solid.

1. temperaturecooled in an ice bath
2. customThe mixture was evaporated
3. customthe residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate
4. customThe organic layer was separated out
5. extractionthe aqueous layer was extracted with dichloromethane
6. dry with materialThe combined organic extracts were dried over sodium sulfate
7. customevaporated
8. washChromatography of the residue over silica gel gradient eluted with 1:99 up to 3:97 methanol in dichloromethane