Sodium hydride → HCID 20325833, compound

Participants

Reaction Steps

Methyl pyrrol-2-ylglyoxylate (306 mg) in diglyme was treated with sodium hydride (63mg) and stirred at room temperature for 3 hr. Benzyloxymethyl chloride (376mg) was added and the mixture stirred at room temperature for a further 3 hr. The suspension was filtered and the filtrate evaporated. The residue, in ether, was washed with sodium bicarbonate solution, water and dried. Evaporation gave the crude product as a brown oil (530mg). Purification by preparative thin-layer chromatography gave the title compound as a colourless oil (250 mg,46%); τ values (DMSO-d6) include 6.10 (--CH3), 4.20 (N-CH2 --). 5.47 (--OCH2 --), 2.70 (--Ph).

Provenance & Evidence