反应详情

A solution of 67 g. (0.19 mole) of 2-(2-bromoacetamido)-5-chloro-benzophenone, 500 ml. of xylene, 15.7 g. (0.21 mole) of 1-amino-2-propanol and 25 ml. of triethylamine was stirred at reflux for 20 hours. The reaction mixture was concentrated in vacuo to a residue which was partitioned between methylene chloride and water. The organic layer was washed with water, dried and concentrated to an oil which was crystallized from ethyl acetate to give 18.3 g. of a colorless solid, m.p. 181°-184°. Thin layer chromatography on Eastman alumina plates with an eluant of 3 parts of hexane and 2 parts of ethyl acetate revealed the presence of two compounds. The product was dissolved in chloroform and chromatographed over Woelm neutral alumina I. A mixture concentrated in the above-titled product (the faster of the two compounds) was collected in 30% ethyl acetate-70% hexane. Recrystallizations from methylene chloride gave colorless prisms, m.p. 188°-189°.

1. temperatureat reflux for 20 hours
2. concentrationThe reaction mixture was concentrated in vacuo to a residue which
3. customwas partitioned between methylene chloride and water
4. washThe organic layer was washed with water
5. customdried
6. concentrationconcentrated to an oil which
7. customwas crystallized from ethyl acetate
8. customto give 18.3 g
9. customchromatographed over Woelm neutral alumina I
10. concentrationA mixture concentrated in the above-titled product (the faster of the two compounds)
11. customwas collected in 30% ethyl acetate-70% hexane
12. customRecrystallizations from methylene chloride
13. customgave colorless prisms, m.p. 188°-189°