Sodium Hydroxide → HCID 12801675, compound

HRID 328568Notes

Reaction equation

HRID 328568 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:19]=[C:18]3[C:13]([C:14](=[O:27])[C:15]([C:22]([O:24]CC)=[O:23])=[CH:16][N:17]3[CH2:20][CH3:21])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)(=O)C>[CH2:20]([N:17]1[C:18]2[C:13](=[CH:12][CH:11]=[C:10]([N:7]3[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]3)[N:19]=2)[C:14](=[O:27])[C:15]([C:22]([OH:24])=[O:23])=[CH:16]1)[CH3:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21442838HCID 21442838, compound

Product 1

HCID 12801675HCID 12801675, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
95 °C

Procedure

To 1.6 g of ethyl 7-(4-acetyl-1-piperazinyl)-1,4-dihydro-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylate was added 15 ml of a 10% aqueous solution of sodium hydroxide. The mixture was heated at 95° C for 1.5 hours, and neutralized, under cooling, with acetic acid to give a precipitate which was collected and recrystallized from water to yield 1.0 g of the product as colorless needles, m.p. 272° - 273° C.

Workup

  1. customto give a precipitate which
  2. customwas collected
  3. customrecrystallized from water

Sources & evidence

ORD record
ord-8bf27c31f26648eaaf68b2c05ceee85d
Source dataset
uspto-grants-1977_04
Patent number
US04017622

Reaction notes

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