Sodium Hydroxide → HCID 12810686, compound

Participants

Reaction Steps

To 0.80 g of ethyl 1-(2-chloroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1,8-naphthyridine-3-carboxylate was added 10 ml of a 10% aqueous solution of sodium hydroxide. The mixture was heated at 90° - 95° C for 30 minutes and neutralized with acetic acid under cooling. The resulting mixture was extracted with chloroform. The extract was washed with water and concentrated to leave a yellow solid which was collected and recrystallized from ethanol to give 0.56 g of the product as pale yellow needles, m.p. 238° - 239° C.

Provenance & Evidence