Acetic Acid → HCID 21442884, compound

Participants

Reaction Steps

350 ml of a 14% strength sodium hypochlorite solution are added dropwise to a suspension of 94 g of 5-acetyl-8-hydroxyquinoline in 1 litre of methanol and 1 litre of water at 10°-20°C, whilst stirring well. After stirring for a further hour, the mixture is acidified with 60 ml of glacial acetic acid and diluted with 1 liter of water, and the product is filtered off. The filter residue is washed with water and recrystallised, whilst still moist, from alcohol. 70 g of almost colourless 5-acetyl-7-chloro-8-hydroxyquinoline are obtained, melting point 163°-166° C.

Provenance & Evidence