Water → HCID 13277198, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (0.03 g) in tetrahydrofuran (5 ml) was added a solution of 5-(4-benzyl-5-oxo-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz-[b,f]azepine (0.5 g) in tetrahydrofuran (15 ml) under ice cooling, and the resulting mixture was stirred at room temperature for 1 hour and refluxed for 10 hours with stirring. The reaction mixture was cooled, admixed with water (2 ml) and extracted with benzene. The benzene extract was washed with water, dried over anhydrous sodium sulfate and evaporated to afford 5-(4-benzyl-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine as an oily substance. M.P. 139°-140° C (oxalate).

Provenance & Evidence