Hydrochloric Acid → HCID 21442787, compound

Participants

Reaction Steps

A mixture of 3-ethyl-5-(2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine (0.3 g), 90% formic acid (0.7 g) and 37% formalin (0.58 ml) was stirred at 90°-100° C for 8 hours. After cooling, 4N hydrochloric acid was added to the reaction mixture. The resulting mixture was evaporated to dryness under reduced pressure. Water was added to the residue, neutralized with aqueous ammonia, and extracted with benzene. The benzene extract was washed with water, dried over anhydrous sodium sulfate and evaporated to afford 3-ethyl-5-(4-methyl-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine as an oily substance. M.P. 168°-170° C (oxalate).

Provenance & Evidence