Hydrochloric Acid → HCID 21442726, compound

Participants

Reaction Steps

To a solution of 0.86 g. of 4-acetoxy-6-(2-chlorophenyl)-8-ethyl-4H-thieno[3,2-f]-s-triazolo[1,5-a][1,4]-diazepine-2-carboxamide in 5 ml. of methanol is added dropwise 2 ml. of a 1N-aqueous sodium hydroxide solution with stirring and ice-cooling. After 5 minutes, to the resulting mixture is added 2 ml. of a 1N-aqueous hydrochloric acid solution and then water. The resulting precipitate is collected by filtration and then washed with water to give 6-(2-chlorophenyl)-8-ethyl-4-hydroxy-4H-thieno[3,2-f]-s-triazolo[1,5-a]-[1,4]diazepine-2-carboxamide as crystals. Recrystallization from ethanol gives colorless prisms melting at 228° to 231° C.

Provenance & Evidence