HCID 21442717, compound → HCID 21442716, compound

Participants

Reaction Steps

To a solution of 0.086 g. of 4-acetoxy-6-(2-chlorophenyl)-8-ethyl-4H-thieno[3,2-f]-s-triazolo[1,5-a][1,4]diazepine-2-carboxamide in 3 ml. of methanol is added one drop of concentrated sulfuric acid and the resulting mixture is refluxed for 5 minutes. After evaporation of the solvent a saturated aqueous sodium hydrogen carbonate solution is added to the residue. The resulting precipitate is collected by filtration to give 6-(2-chlorophenyl)-8-ethyl-4-methoxy-4H-thieno[3,2-f]-s-triazolo[1,5-a][1,4]diazepine-2-carboxamide as crystals. Recrystallization from ethyl acetate gives powdery crystals melting at 200° to 201° C.

Provenance & Evidence