Methanol → HCID 21442716, compound

Participants

Reaction Steps

To a solution of 0.86 g. of 6-(2-chlorophenyl)-8-ethyl-4-hydroxy-4H-thieno[3,2-f]-s-triazolo[1,5-a][1,4]-diazepine-2-carboxamide in 20 ml. of methanol is added one drop of concentrated sulfuric acid. The resulting mixture is refluxed for 5 minutes. After evaporation of the solvent a saturated sodium hydrogen carbonate solution is added to the residue, and the resulting precipitate is collected by filtration to give 6-(2-chlorophenyl)-8-ethyl-4-methoxy-4H-thieno[3,2-f]-s-triazolo[1,5-a][1,4]diazepine-2-carboxamide as crystals melting at 200° to 201° C. This product is identical with the product obtained in Example 3 with respect to the melting point and infra red absorption spectrum thereof.

Provenance & Evidence