Hydrochloric Acid → HCID 70634905, compound

Participants

Reaction Steps

A solution of 21-acetyloxy-11β-bromo-9-fluoro-17-hydroxypregn-4-ene-3,20-dione (4.0 g) in pyridine (10 ml) is cooled to 10° C. A solution of N-bromosuccinimide (2.0 g) in pyridine (7.0 ml) is added at 10° C and the mixture is warmed to room temperature and stirred for 10 minutes. It is recooled to 10° C and a solution of sulfur dioxide (2.2 g) in pyridine (10 ml) is added. The mixture is warmed to room temperature and then added slowly, with stirring into 1N hydrochloric acid (300 ml). The title compound is separated and purified.

Provenance & Evidence