3,4-Dimethylphenol → 1,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one

HRID 328671Notes

Reaction equation

HRID 328671 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[C:10]([CH:15]1[C:20](=O)[CH2:19][CH2:18][NH:17][CH2:16]1)(OCC)=[O:11]>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]2[C:20]3[CH2:19][CH2:18][NH:17][CH2:16][C:15]=3[C:10](=[O:11])[O:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 72493,4-DimethylphenolHCID 1073164-Oxo-piperidine-3-carboxylic acid ethyl ester

Product 1

HCID 131369151,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Procedure

In the same way as described for example 1, 0.3m of 3,4-dimethyl phenol, 0.2m of 3-carbethoxy-4piperidone were reacted to give 8.4g of crude product. Crystallization from ethyl acetate afforded analytical material, m.p. 173°-5° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3f227936684c456b94737ea685a8029b
Source dataset
uspto-grants-1977_04
Patent number
US04018766

Reaction notes

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