HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine, 1-(2-chloroethyl)-, hydrochloride → 1,2,3,4-Tetrahydro-8,9-dimethyl-3[2-(piperidino)-ethyl]-5H-[1]benzopyrano[3,4-c]pyridine-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | 1,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 13136915 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1,2,3,4-Tetrahydro-8,9-dimethyl-3[2-(piperidino)-ethyl]-5H-[1]benzopyrano[3,4-c]pyridine-5-one | HCID 13361016 | 80.2% |
Reaction Steps
In the same way as described in example 3, 4.2g of 1,2,3,4-tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, 4.05g of N-chloroethylpiperidine hydrochloride and 4.4g of triethylamine gave 5.0g of crude base. Crystallization from actronitrile gave analytical material, m.p. 142°-5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018766 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-b7095acb89464063838982a75d02fcc6 |
| Source note | uspto-grants-1977_04 |