HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyphenyl)piperazine → HCID 70619452, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 1a,2,7,7a-Tetrahydro-3,6-dimethoxynaphth[2,3-b]oxirene | HCID 12367003 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 70619452 | HCID 70619452 | 50.4% |
Reaction Steps
A solution of 4.12 g of 6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene, 4.81 g of 1-(o-methoxyphenyl)piperazine, and 1.53 ml of isopropyl alcohol in 20 ml of xylene is refluxed under nitrogen for 19 hours. The xylene is removed in vacuo and the residue triturated with ether to give 4.01 g of crude material. Two recrystallizations of this material from ethyl acetate yield 2.5 g of the title compound, melting point 182°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018773 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-d2b0115da3c548ff92c9e820240182a3 |
| Source note | uspto-grants-1977_04 |