HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 70619733, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-(3-(Trifluoromethyl)phenyl)piperazine | HCID 4296 | — |
| Reactant | 1a,2,7,7a-Tetrahydro-3,6-dimethoxynaphth[2,3-b]oxirene | HCID 12367003 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 70619733 | HCID 70619733 | 36.7% |
Reaction Steps
A solution of 10.3 g of 2,3-epoxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene, 11.5 g of N-(α,α,α-trifluoro-m-tolyl)piperazine, and 2 ml of absolute ethanol in 100 ml of xylene is refluxed for 7 days. The reaction mixture is concentrated in vacuo, and the residue is triturated with ether to give 11.9 g of crude product. Recrystallization from ethyl acetate gives 8.0 g of the title compound, melting point 184°-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04018773 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-12ff8802158041f4929a27273052f6a9 |
| Source note | uspto-grants-1977_04 |