Potassium → HCID 68118258, compound

HRID 328708Notes

Reaction equation

HRID 328708 reaction equation
Cl.[NH2:2][CH2:3][CH:4]([OH:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:14][CH:15]=[CH2:16].[K].[C:19]([CH:27]=[C:28](O)[CH3:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>C(O)C>[C:19]([CH:27]=[C:28]([NH:2][CH2:3][CH:4]([OH:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:14][CH:15]=[CH2:16])[CH3:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

Participants

5

Reactant 3

HCID 5462222PotassiumHCID 20223081HCID 20223081, compoundHCID 178467982HCID 178467982, compound

Product 1

HCID 68118258HCID 68118258, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.1 g of 1-amino-3-(o-allyloxyphenoxy)-propan-2-ol hydrochloride ##STR30## are suspended in 50 ml of ethanol, 4 g of the potassium salt of 2-nicotinoyl-1-methyl-vinyl alcohol ##STR31## are then added and the mixture is stirred for 24 hours at room temperature. The suspension is filtered off and the residue is washed with ethanol. The filtrate, together with the wash alcohol is concentrated in vacuo. An oil is left, which solidifies after a short time. The oil which has solidified, together with the residue left on washing with alcohol, is repeatedly triturated with water and then recrystallised from ethanol. 1-(2-Nicotinoyl-1-methyl-vinylamino)-3-(o-allyloxyphenoxy)-propan-2-ol of the formula ##STR32## is thus obtained.

Workup

  1. filtrationThe suspension is filtered off
  2. washthe residue is washed with ethanol
  3. concentrationThe filtrate, together with the wash alcohol is concentrated in vacuo
  4. waitAn oil is left
  5. waitleft
  6. washon washing with alcohol
  7. customis repeatedly triturated with water
  8. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-f5adee1185234ead9e9b26434cb64cbb
Source dataset
uspto-grants-1977_04
Patent number
US04018778

Reaction notes

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