HCID 21439841, compound → HCID 21439847, compound

HRID 328712Notes

Reaction equation

HRID 328712 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]2[S:6][C:7]3[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=3[C:4]=2[CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]2[S:6][C:5]3[CH:16]=[CH:17][C:2]([F:1])=[CH:3][C:4]=3[C:8]=2[CH:9]=1

Participants

5

Reactant 2

HCID 21439841HCID 21439841, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21439847HCID 21439847, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 14.33 g. (0.0605 mole) of 2-fluoro-8-nitrodibenzothiophene in 550 ml. of ethanol and about one-half teaspoonful (about 2.5 ml.) of Raney nickel is hydrogenated at about 30 psi of hydrogen gas in a Paar apparatus for about 48 hours. The mixture is filtered, and the filtrate is evaporated to dryness under vacuum to provide white needles of 2-amino-8-fluorodibenzothiophene, m.p. 131°-132° C.

Workup

  1. additionA mixture of 14.33 g
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness under vacuum

Sources & evidence

ORD record
ord-297c0048d64842c982103ebf38aa70ba
Source dataset
uspto-grants-1977_04
Patent number
US04018780

Reaction notes

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