Phosphorus sulfide (P2S5) → 1,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepine-2-thione

HRID 328720Notes

Reaction equation

HRID 328720 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:21]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[S:21])[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 214401071,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepin-2-one

Product 1

HCID 214401081,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepine-2-thione

Procedure

A mixture of 1,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepin-2-one and P2S5 can be reacted in the same manner as in Preparation I to produce 1,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepine-2-thione. This latter compound can then be substituted in the procedure of Example 1 to produce 6-(o-bromophenyl)-1-methyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine.

Workup

  1. customcan be reacted in the same manner as in Preparation I

Sources & evidence

ORD record
ord-c06fdb66ab994594aa74261e908f8555
Source dataset
uspto-grants-1977_04
Patent number
US04018788

Reaction notes

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