Methyl iodide → HCID 21439971, compound

Participants

Reaction Steps

A mixture of ethyl 2-[4-(N-thiazol-2-ylamino)phenyl]propionate (6.3g), methyl iodide (30 ml) and ethanol (30 ml) is heated at 50°-55° C for 20 hours under nitrogen atmosphere. After evaporation of ethanol and methyl iodide, the resultant residue is washed with ether and ethyl acetate successively to give 3-methyl-2-[4-(1-ethoxycarbonylethyl)anilino]thiazolium iodide (8.0 g). (Yield 84 %).

Provenance & Evidence