反应详情

A mixture of ethyl 2-[3-fluoro-4-(N-thiazol-2-ylamino)phenyl]propionate (11.l g), methyl iodide (44.5 ml) and ethanol (44.5 ml) is heated at 50°-55° C for 48 hours. The resultant mixture is treated in the same manner as in Example (1) and (2) to give ethyl 2-[3-fluoro-4-(3-methyl-4-thiazolin -2-ylideneamino)phenyl]propionate (6.8 g). (Yield 58.5 %).

1. temperatureis heated at 50°-55° C for 48 hours